Alterations of RB1 gene in embryonal and alveolar rhabdomyosarcoma: special reference to utility of pRB immunoreactivity in differential diagnosis of rhabdomyosarcoma subtype.

doi:10.1007/s00432-008-0385-3

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Alterations of RB1 gene in embryonal and alveolar rhabdomyosarcoma: special reference to utility of pRB immunoreactivity in differential diagnosis of rhabdomyosarcoma subtype.

Journal of cancer research and clinical oncology - 1 Oct 2008

Kohashi Kenichi, Oda Yoshinao, Yamamoto Hidetaka, Tamiya Sadafumi, Takahira Tomonari, Takahashi Yukiko, Tajiri Tatsuro, Taguchi Tomoaki, Suita Sachiyo, Tsuneyoshi Masazumi

Abstract excerpt

PURPOSE: Rhabdomyosarcoma (RMS), which is the most common pediatric soft tissue sarcoma, is classified into two major histologic subtypes, embryonal RMS (ERMS) and alveolar RMS (ARMS). RMS is occasionally reported to be the second neoplasm of hereditary retinoblastoma. Osteosarcoma is known as the most common second neoplasm of hereditary retinoblastoma, and tumorigenesis of osteosarcoma has been proven in...

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Alterations of RB1 gene in embryonal and alveolar rhabdomyosarcoma: special reference to utility of pRB immunoreactivity in differential diagnosis of rhabdomyosarcoma subtype.

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