Structural principles that govern the peptide-binding motifs of class I MHC molecules.

Abstract excerpt

The peptides that bind class I MHC molecules are restricted in length and often contain key amino acids, anchor residues, at particular positions. The side-chains of peptide anchor residues interact with the polymorphic complementary pockets in MHC peptide-binding grooves and provide the molecula...

Topics

• Alleles
• Amino Acids
• Binding Sites
• Databases as Topic
• Evolution, Molecular
• Histocompatibility Antigens Class I
• Ligands
• Models, Molecular
• Peptides
• Protein Binding
• Sequence Alignment
• Static Electricity