Class I MHC-peptide interaction: structural and functional aspects.

Article

Class I MHC-peptide interaction: structural and functional aspects.

Behring Institute Mitteilungen - 1 Jul 1994

Ruppert J, Kubo R T, Sidney J, Grey H M, Sette A

Abstract excerpt

The structural requirements for the interaction between antigens and class I molecules was investigated through the use of a quantitative assay to measure peptide binding to different MHC class I alleles. We determined the permissiveness of the main anchors reported by Rammensee and his group for...

Topics

Alleles
Amino Acid Sequence
Binding Sites
Genes, MHC Class I
HLA-A2 Antigen
Histocompatibility Antigens Class I
Humans
Molecular Sequence Data
Peptides
Structure-Activity Relationship
T-Lymphocytes, Cytotoxic

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