Article
Polymorphisms in pockets of major histocompatibility complex class I molecules influence peptide preference.
The Journal of experimental medicine - 1 Jun 1993
Rohren E M, Pease L R, Ploegh H L, Schumacher T N
Abstract excerpt
The set of peptides that is bound by a given major histocompatibility complex class I product can be described by one or two properly spaced anchor residues, and two properly spaced peptide termini, approximately 8-10 residues apart. Using radiolabeled peptide libraries, we examined whether mutat...
Topics
- Amino Acid Sequence
- Animals
- Cells, Cultured
- H-2 Antigens
- Mice
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Polymorphism, Genetic
- Structure-Activity Relationship