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Article

Methyl-donor depletion of head and neck cancer cells in vitro establishes a less aggressive tumour cell phenotype.

European journal of nutrition - 1 Jun 2018

Hearnden Vanessa, Powers Hilary J, Elmogassabi Abeir, Lowe Rosanna, Murdoch Craig

Abstract excerpt

PURPOSE: DNA methylation plays a fundamental role in the epigenetic control of carcinogenesis and is, in part, influenced by the availability of methyl donors obtained from the diet. In this study, we developed an in-vitro model to investigate whether methyl donor depletion affects the phenotype and gene expression in head and neck squamous cell carcinoma (HNSCC) cells. METHODS: HNSCC cell lines (UD-SCC2 and...

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Source

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Identifiers

PMID: 28251343
DOI: 10.1007/s00394-017-1411-5
PMCID: PMC5959985

Genes

DAPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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