Article
A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage.
Cancer research - 15 Jun 1995
Aquilina G, Hess P, Fiumicino S, Ceccotti S, Bignami M
Abstract excerpt
Sixty % of clones isolated from HeLa cells treated with toxic concentrations of a methylating carcinogen showed increased resistance to the cytotoxicity of N-methyl-N-nitrosourea. D37 values were 6- to 100-fold higher than in the parental cell population. The absence of detectable levels of the repair enzyme O6-methylguanine-DNA methyltransferase indicated that the resistant clones were able to tolerate the...
Topics
- Cell Survival
- DNA Damage
- DNA Repair
- DNA, Neoplasm
- DNA, Satellite
- Dose-Response Relationship, Drug
- Drug Resistance
- Genetic Complementation Test
- Guanine
- HeLa Cells
- Humans