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A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage.

Cancer research - 15 Jun 1995

Aquilina G, Hess P, Fiumicino S, Ceccotti S, Bignami M

Abstract excerpt

Sixty % of clones isolated from HeLa cells treated with toxic concentrations of a methylating carcinogen showed increased resistance to the cytotoxicity of N-methyl-N-nitrosourea. D37 values were 6- to 100-fold higher than in the parental cell population. The absence of detectable levels of the repair enzyme O6-methylguanine-DNA methyltransferase indicated that the resistant clones were able to tolerate the...

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PMID: 7780970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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