Article
The Biological Basis of Histologic Transformation.
Hematology/oncology clinics of North America - 1 Aug 2020
Kumar Emil A, Okosun Jessica, Fitzgibbon Jude
Abstract excerpt
Histologic transformation of follicular lymphoma remains the leading cause of follicular lymphoma-related mortality in the rituximab era. Both the diverse timing of transformation and heterogeneity in associated genomic events suggest that histologic transformation may itself comprise distinct disease entities. Successive indolent and transformation episodes occur by divergent clonal evolution from an inferred...
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