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Article

Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma.

Leukemia research - 1 Jul 2008

Halldórsdóttir Anna Margrét, Frühwirth Margareta, Deutsch Alexander, Aigelsreiter Ariane, Beham-Schmid Christine, Agnarsson Bjarni A, Neumeister Peter, Richard Burack W

Abstract excerpt

Somatic hypermutation (SHM) aberrantly targets proto-oncogenes in various non-Hodgkin's lymphoma. To test the association of SHM with transformation of follicular lymphoma (FL), we sequenced mutational hot spots in five proto-oncogenes (BCL6, PAX5, RHOH, MYC and PIM1) in 32 low-grade FL (lgFL) with follicular histology and 26 transformed FL (tFL) with diffuse large cell histology. No difference was detected in...

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Share to Cell Transformation, Neoplastic
Share to BCL6 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, Follicular

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Source

Identifiers

PMID: 18180034
DOI: 10.1016/j.leukres.2007.11.028

Genes

BCL6
MYC
PAX5
PIM1
RHOH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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