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Article

Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene

15 Nov 1996

Abstract excerpt

Follicular lymphoma (FL) is a low-grade B-cell non-Hodgkin's lymphoma (NHL) that frequently transforms into diffuse aggressive NHL. The majority of FLs display a t(14; 18) translocation that places the bcl-2 gene into juxtaposition with the lg heavy-chain (H) gene locus. Morphologically transformed malignant FL cells retain their t(14;18) translocation and may acquire additional genetic abnormalities. We analyzed...

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Identifiers

PMID: 8916960
DOI: 10.1182/blood.v88.10.3937.bloodjournal88103937

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