Article
p53 alterations in sequential biopsies of Asian follicular lymphoma: a study of immunohistochemical staining pattern and gene mutations by PCR-SSCP in paraffin-embedded tissues.
Pathology - 1 Feb 2005
Shaminie J, Peh S C, Tan Jama
Abstract excerpt
AIM: Tumour suppressor gene p53 is a common target in carcinogenesis, reported to be altered and functionally inactive in 70% of human cancers. Although p53 mutations are less commonly present in haematological malignancies when compared with other solid tumours, they have been reported in histological transformation of follicular lymphoma. We aimed to investigate the frequency of p53 gene alterations in...
Topics
- Adult
- Aged
- Asian People
- Female
- Gene Expression
- Humans
- Immunohistochemistry
- Lymphoma, Follicular
- Male
- Middle Aged
- Mutation
- Paraffin Embedding
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Tumor Suppressor Protein p53