Article
Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study.
PLoS medicine - 1 Dec 2016
Kridel Robert, Chan Fong Chun, Mottok Anja, Boyle Merrill, Farinha Pedro, Tan King, Meissner Barbara, Bashashati Ali, McPherson Andrew, Roth Andrew, Shumansky Karey, Yap Damian, Ben-Neriah Susana, Rosner Jamie, Smith Maia A, Nielsen Cydney, Giné Eva, Telenius Adele, Ennishi Daisuke, Mungall Andrew, Moore Richard, Morin Ryan D, Johnson Nathalie A, Sehn Laurie H, Tousseyn Thomas, Dogan Ahmet, Connors Joseph M, Scott David W, Steidl Christian, Marra Marco A, Gascoyne Randy D, Shah Sohrab P
Abstract excerpt
BACKGROUND: Follicular lymphoma (FL) is an indolent, yet incurable B cell malignancy. A subset of patients experience an increased mortality rate driven by two distinct clinical end points: histological transformation and early progression after immunochemotherapy. The nature of tumor clonal dynamics leading to these clinical end points is poorly understood, and previously determined genetic alterations do not...
Topics
- Clonal Evolution
- Clone Cells
- Disease Progression
- Humans
- Lymphoma, Follicular
- Mutation