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Article

Genetic Variation Determines Mast Cell Functions in Experimental Asthma

14 May 2011

Abstract excerpt

Mast cell-deficient mice are a key for investigating the function of mast cells in health and disease. Allergic airway disease induced as a Th2-type immune response in mice is employed as a model to unravel the mechanisms underlying inception and progression of human allergic asthma. Previous work done in mast cell-deficient mouse strains that otherwise typically mount Th1-dominated immune responses revealed...

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PMID: 21572035
DOI: 10.4049/jimmunol.1100676

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