Article
B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency.
The Journal of experimental medicine - 24 Nov 2008
Gupta Vikas A, Hermiston Michelle L, Cassafer Gail, Daikh David I, Weiss Arthur
Abstract excerpt
CD45 and Fas regulate tyrosine phosphorylation and apoptotic signaling pathways, respectively. Mutation of an inhibitory wedge motif in CD45 (E613R) results in hyperresponsive thymocytes and B cells on the C57BL/6 background, but no overt autoimmunity, whereas Fas deletion results in a mild autoimmune disease on the same genetic background. In this study, we show that these two mutations cooperate in mice,...
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