Article
The lack of a role for p53 in astrocytomas in pediatric patients.
Neurosurgery - 1 Jun 1994
Litofsky N S, Hinton D, Raffel C
Abstract excerpt
Mutations in the p53 gene, which codes for a cell division regulatory protein, have been identified in approximately one-third of adult astrocytomas. We evaluated 35 astrocytic tumors (17 pilocytic, 4 diffuse low grade, 12 anaplastic, and 2 glioblastoma) in pediatric patients for p53 mutations, u...
Topics
- Adolescent
- Astrocytoma
- Biomarkers, Tumor
- Brain Neoplasms
- Cell Transformation, Neoplastic
- Child
- Child, Preschool
- Female
- Gene Expression Regulation, Neoplastic
- Glioblastoma
- Humans
- Infant
- Male
- Mutation
- Polymerase Chain Reaction
- Tumor Suppressor Protein p53