Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation.

doi:10.1016/0167-5699(93)90145-B

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Article

Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation.

Immunology today - 1 Aug 1993

Kepler T B, Perelson A S

Abstract excerpt

Affinity maturation of the humoral immune response by somatic hypermutation is marked by a rapid and dramatic increase in affinity for the eliciting antigen. We suggest that the optimal mutation schedule is one in which periods of rapid mutation alternate with periods of mutation-free growth. The...

Topics

B-Lymphocytes
Germ Cells
Immunoglobulin Variable Region
Mathematics
Mutation

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