Article
Identification of a fifth neutralizable site on type O foot-and-mouth disease virus following characterization of single and quintuple monoclonal antibody escape mutants.
The Journal of general virology - 1 Aug 1993
Crowther J R, Farias S, Carpenter W C, Samuel A R
Abstract excerpt
A monoclonal antibody (C3) produced against foot-and-mouth disease virus type O1Caseros was found to neutralize quadrivalent monoclonal antibody escape mutant (G67) of foot-and-mouth disease virus type O1Kaufbeuren. This mutant had been characterized at the sequence level as having distinct changes affecting four non-overlapping neutralizable sites. The C3 monoclonal antibody was used to prepare a quintuple...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Antigens, Viral
- Aphthovirus
- Cattle
- Enzyme-Linked Immunosorbent Assay
- Guinea Pigs
- Molecular Sequence Data
- Mutation
- Neutralization Tests