Article
The mechanism of differential neutralization of dengue serotype 3 strains by monoclonal antibody 8A1.
Virology - 25 Apr 2013
Zhou Yang, Austin S Kyle, Fremont Daved H, Yount Boyd L, Huynh Jeremy P, de Silva Aravinda M, Baric Ralph S, Messer William B
Abstract excerpt
While previous studies have demonstrated that envelope (E) glycoprotein variation between dengue viruses (DENV) genotypes can influence antibody neutralization potency, the mechanisms of variable neutralization remain incompletely understood. Here we characterize epitope antibody interactions of a DENV-3 EDIII binding mouse mAb 8A1 which displays highly variable neutralizing activity against DENV-3 genotypes....
Topics
- Aedes
- Amino Acid Substitution
- Animals
- Antibodies, Monoclonal
- Antibodies, Neutralizing
- Cell Line
- Dengue Virus
- Enzyme-Linked Immunosorbent Assay
- Epitopes
- Genotype
- Humans
- Mice
- Mutant Proteins
- Mutation, Missense