A novel universal neutralizing monoclonal antibody against enterovirus 71 that targets the highly conserved "knob" region of VP3 protein.

doi:10.1371/journal.pntd.0002895

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Article

A novel universal neutralizing monoclonal antibody against enterovirus 71 that targets the highly conserved "knob" region of VP3 protein.

PLoS neglected tropical diseases - 1 Jan 2014

Kiener Tanja K, Jia Qiang, Meng Tao, Chow Vincent Tak Kwong, Kwang Jimmy

Abstract excerpt

Hand, foot and mouth disease caused by enterovirus 71(EV71) leads to the majority of neurological complications and death in young children. While putative inactivated vaccines are only now undergoing clinical trials, no specific treatment options exist yet. Ideally, EV71 specific intravenous immunoglobulins could be developed for targeted treatment of severe cases. To date, only a single universally neutralizing...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antibodies, Neutralizing
Brain
Capsid Proteins
Chlorocebus aethiops
Enterovirus A, Human
Enterovirus Infections
Epitopes
Humans
Mice
Mice, Inbred BALB C

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Molecular Sequence Data

Mutation

Sequence Alignment

Vero Cells

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Identifiers

PMID: 24875055
DOI: 10.1371/journal.pntd.0002895
PMCID: PMC4038473

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