Sequence analysis of monoclonal antibody resistant mutants of type O foot and mouth disease virus: evidence for the involvement of the three surface exposed capsid proteins in four antigenic sites.

Abstract excerpt

Sequence analysis of monoclonal antibody resistant mutants of type O foot and mouth disease virus has been performed. Distinct clusters of amino acid substitutions conferring resistance to neutralization at each of the four previously defined antigenic sites (McCahon et al., 1989, J. Gen. Virol. 70, 639-645) have been identified. One site corresponds to the well-known 140-160 region of VP1, a second site is also...

Topics

• Animals
• Antibodies, Monoclonal
• Aphthovirus
• Capsid
• Cell Line
• Epitopes
• Models, Molecular
• Mutation
• Neutralization Tests
• Protein Conformation