Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites.

Abstract excerpt

Antigenic variation in a major discontinuous site (site D) of foot-and-mouth disease virus (FMDV) of serotype C has been evaluated with neutralizing monoclonal antibodies. Isolates representing the major evolutionary sublines previously defined for serotype C were compared. Extensive variation, c...

Topics

• Amino Acid Sequence
• Antibodies, Monoclonal
• Antibodies, Viral
• Antigens, Viral
• Aphthovirus
• Capsid
• Capsid Proteins
• Genetic Variation
• Immunodominant Epitopes
• Models, Molecular
• Molecular Sequence Data
• Sequence Homology, Amino Acid
• Serotyping