Article
Generation of a subtype-specific neutralization epitope in foot-and-mouth disease virus of a different subtype.
The Journal of general virology - 1 Jan 1992
Hernández J, Martínez M A, Rocha E, Domingo E, Mateu M G
Abstract excerpt
An epitope involved in neutralization of foot-and-mouth disease virus (FMDV) of subtype C3 was generated by a single amino acid replacement in VP1 of FMDV of subtype C1. The replacement [Ser (139)----Ile, in the immunodominant site A] was consistently found in those FMDV C1 Santa Pau-Sp/70 mutants resistant to neutralization by monoclonal antibody (MAb) SD6 (specific for most C1 viruses) that acquired the...
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