Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of a subtype-specific neutralization epitope in foot-and-mouth disease virus of a different subtype.

The Journal of general virology - 1 Jan 1992

Hernández J, Martínez M A, Rocha E, Domingo E, Mateu M G

Abstract excerpt

An epitope involved in neutralization of foot-and-mouth disease virus (FMDV) of subtype C3 was generated by a single amino acid replacement in VP1 of FMDV of subtype C1. The replacement [Ser (139)----Ile, in the immunodominant site A] was consistently found in those FMDV C1 Santa Pau-Sp/70 mutants resistant to neutralization by monoclonal antibody (MAb) SD6 (specific for most C1 viruses) that acquired the...

Topics

Amino Acid Sequence
Antibodies, Monoclonal
Antigens, Viral
Aphthovirus
Epitopes
Molecular Sequence Data
Mutation
Neutralization Tests
Viral Plaque Assay

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1370534
DOI: 10.1099/0022-1317-73-1-213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1370534-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of a subtype-specific neutralization epitope in foot-and-mouth disease virus of a different subtype.PMID 1370534Read ↗

A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype CSemantic proximity Read ↗

A highly divergent antigenic site of foot-and-mouth disease virus retains its immunodominance.Semantic proximity Read ↗

Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites.Semantic proximity Read ↗

Identification of a fifth neutralizable site on type O foot-and-mouth disease virus following characterization of single and quintuple monoclonal antibody escape mutants.Semantic proximity Read ↗

Distinct repertoire of antigenic variants of foot-and-mouth disease virus in the presence or absence of immune selectionSemantic proximity Read ↗

A Similar Pattern of Interaction for Different Antibodies with a Major Antigenic Site of Foot-and-Mouth Disease Virus: Implications for Intratypic Antigenic VariationSemantic proximity Read ↗

Insertion of type O-conserved neutralizing epitope into the foot-and-mouth disease virus type Asia1 VP1 G-H loop: effect on viral replication and neutralization phenotype.Semantic proximity Read ↗

Capsid protein-encoding (P1) sequence of foot and mouth disease virus type Asia 1 ind 63/72.Semantic proximity Read ↗

The structure and antigenicity of a type C foot-and-mouth disease virusSemantic proximity Read ↗

Mapping of antigenic sites of foot-and-mouth disease virus serotype Asia 1 and relationships with sites described in other serotypesSemantic proximity Read ↗

Mutation in the 1D gene (VP1) of Foot-and-mouth disease virus serotype Asia1 during serial cytolytic infections in cell culture.Semantic proximity Read ↗

Unique amino acid substitutions in the capsid proteins of foot-and-mouth disease virus from a persistent infection in cell cultureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.