Article
Monoclonal antibodies, against O1 serotype foot-and-mouth disease virus, from a natural bovine host, recognize similar antigenic features to those defined by the mouse.
The Journal of general virology - 1 Jul 1998
Barnett P V, Samuel A R, Pullen L, Ansell D, Butcher R N, Parkhouse R M
Abstract excerpt
Eight neutralizing and two non-neutralizing anti-foot-and-mouth disease virus (FMDV) bovine IgG1 and IgG2 monoclonal antibodies (BMAbs) recognize conformationally dependent epitopes. The majority of those shown to neutralize virus passively protected mice from virus challenge, regardless of isoty...
Topics
- Animals
- Antibodies, Monoclonal
- Antibodies, Viral
- Antibody Specificity
- Antigens, Viral
- Aphthovirus
- Binding, Competitive
- Capsid
- Capsid Proteins
- Cattle
- Cell Line
- Cricetinae
- Foot-and-Mouth Disease
- Mice
- Models, Molecular
- Mutation
- Neutralization Tests
- Protein Conformation