Differential expression of domain III neutralizing epitopes on the envelope proteins of West Nile virus strains.

doi:10.1016/j.virol.2005.02.011

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Article

Differential expression of domain III neutralizing epitopes on the envelope proteins of West Nile virus strains.

Virology - 25 Apr 2005

Li Li, Barrett Alan D T, Beasley David W C

Abstract excerpt

Neutralization of flaviviruses by antibody is primarily mediated via epitopes in the viral envelope (E) protein. Comparative studies using neutralizing monoclonal antibodies revealed differential expression of epitopes within the E protein domain III of ten naturally occurring West Nile virus strains representing major subtypes of genetic lineages 1 and 2. Residues that defined these subtype-specific determinants...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antibodies, Viral
Antigenic Variation
Chlorocebus aethiops
Epitopes
Humans
Models, Molecular
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Neutralization Tests
Recombinant Fusion Proteins
Vero Cells
Viral Envelope Proteins
West Nile virus

Source

Open in PubMed

Identifiers

PMID: 15823609
DOI: 10.1016/j.virol.2005.02.011

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