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Article

Visualization and quantification of monoallelic TCRα gene rearrangement in αβ T cells.

Immunology and cell biology - 1 Jan 2000

Winter Manuel, Kashani Elham, Chennupati Vijaykumar, Föhse Lisa, Prinz Immo

Abstract excerpt

T-cell receptor α (TCRα) chain rearrangement is not constrained by allelic exclusion and thus αβ T cells frequently have rearranged both alleles of this locus. Thereby, stepwise secondary rearrangements of both TCRα loci further increase the odds for generation of an α-chain that can be positively selected in combination with a pre-existing TCRβ chain. Previous studies estimated that approximately 2-12% of murine...

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Identifiers

PMID: 24418818
DOI: 10.1038/icb.2013.105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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