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Article

Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus.

Immunity - 1 Nov 1997

Aifantis I, Buer J, von Boehmer H, Azogui O

Abstract excerpt

Following the recent realization that TCR beta transgenes can severely inhibit the rearrangement of endogenous Vbeta gene segments in the absence of pre-TCR alpha (pT alpha) chains, we tested whether the pre-TCR has an essential role in TCR beta allelic exclusion under more physiological conditions by analyzing TCR rearrangement in immature thymocytes by single-cell PCR. Our results in pT alpha+ mice are...

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Source

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PMID: 9390684
DOI: 10.1016/s1074-7613(00)80381-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus.PMID 9390684Read ↗

Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene.Semantic proximity Read ↗

Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment.Semantic proximity Read ↗

Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus.Semantic proximity Read ↗

A critical lineage-nonspecific role for pTalpha in mediating allelic and isotypic exclusion in TCRbeta-transgenic mice.Semantic proximity Read ↗

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.Semantic proximity Read ↗

T cell receptor (TcR) beta chain transgenic mice: studies on allelic exclusion and on the TcR+ gamma/delta population.Semantic proximity Read ↗

Exclusion and inclusion of alpha and beta T cell receptor alleles.Semantic proximity Read ↗

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.Semantic proximity Read ↗

Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.Semantic proximity Read ↗

Ordered and coordinated rearrangement of the TCR alpha locus: role of secondary rearrangement in thymic selection.Semantic proximity Read ↗

Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes.Semantic proximity Read ↗

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