Article
Rearrangement and diversity of T cell receptor beta chain genes in thymocytes: a critical role for the beta chain in development.
Cell - 7 May 1993
Mallick C A, Dudley E C, Viney J L, Owen M J, Hayday A C
Abstract excerpt
Thymocytes from mice congenitally deficient for TCR alpha chain synthesis were examined for the status of their TCR beta chain genes, by DNA sequencing and by a novel technique that analyzes populations of gene rearrangements. TCR beta chain genes were predominantly productively rearranged, in co...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Cloning, Molecular
- DNA
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Genetic Variation
- Genotype
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Receptors, Antigen, T-Cell, alpha-beta
- Restriction Mapping
- T-Lymphocytes
- Thymus Gland