Mouse neurovirulence determinants of poliovirus type 1 strain LS-a map to the coding regions of capsid protein VP1 and proteinase 2Apro.

doi:10.1128/JVI.68.11.7507-7515.1994

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Article

Mouse neurovirulence determinants of poliovirus type 1 strain LS-a map to the coding regions of capsid protein VP1 and proteinase 2Apro.

Journal of virology - 1 Nov 1994

Lu H H, Yang C F, Murdin A D, Klein M H, Harber J J, Kew O M, Wimmer E

Abstract excerpt

Poliovirus type 1 strain LS-a [PV1(LS-a)] is a OV variant adapted to mice by multiple passages through mouse and monkey tissues. To investigate the molecular basis underlying mouse neurovirulence of PV1(LS-a), a cDNA of the viral genome containing nucleotides 112 to 7441 was cloned, and the nucleotide sequence was determined. Compared with that of the mouse avirulent progenitor PV1(Mahoney), 54 nucleotide changes...

Topics

Animals
Base Sequence
Capsid
Capsid Proteins
Cysteine Endopeptidases
DNA, Complementary
Female
Genes, Viral
HeLa Cells
Hot Temperature
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Poliovirus

Structure-Activity Relationship

Viral Proteins

Virulence

Source

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Identifiers

PMID: 7933134
DOI: 10.1128/JVI.68.11.7507-7515.1994
PMCID: PMC237193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7933134-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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