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Article

Substitutions in the capsids of poliovirus mutants selected in human neuroblastoma cells confer on the Mahoney type 1 strain a phenotype neurovirulent in mice.

Journal of virology - 1 Dec 1994

Couderc T, Guédo N, Calvez V, Pelletier I, Hogle J, Colbère-Garapin F, Blondel B

Abstract excerpt

Poliovirus (PV) type 1 mutants selected in human neuroblastoma cells persistently infected (PVpi) with the wild-type Mahoney strain exhibited a mouse-neurovirulent phenotype. Four of the five substitutions present in the capsid proteins of a PVpi were demonstrated to extend the host range of the Mahoney strain to mice. These new mouse-neurovirulent determinants were located in the three-dimensional structure of...

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Identifiers

PMID: 7966631
DOI: 10.1128/JVI.68.12.8386-8391.1994
PMCID: PMC237308

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