Substitutions in the capsids of poliovirus mutants selected in human neuroblastoma cells confer on the Mahoney type 1 strain a phenotype neurovirulent in mice.

doi:10.1128/JVI.68.12.8386-8391.1994

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Article

Substitutions in the capsids of poliovirus mutants selected in human neuroblastoma cells confer on the Mahoney type 1 strain a phenotype neurovirulent in mice.

Journal of virology - 1 Dec 1994

Couderc T, Guédo N, Calvez V, Pelletier I, Hogle J, Colbère-Garapin F, Blondel B

Abstract excerpt

Poliovirus (PV) type 1 mutants selected in human neuroblastoma cells persistently infected (PVpi) with the wild-type Mahoney strain exhibited a mouse-neurovirulent phenotype. Four of the five substitutions present in the capsid proteins of a PVpi were demonstrated to extend the host range of the Mahoney strain to mice. These new mouse-neurovirulent determinants were located in the three-dimensional structure of...

Topics

Amino Acid Sequence
Animals
Base Sequence
Capsid
Cell Line
DNA Primers
Genome, Viral
Humans
Mice
Models, Molecular
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Neuroblastoma

Phenotype

Point Mutation

Poliovirus

Polymerase Chain Reaction

Protein Conformation

Source

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Identifiers

PMID: 7966631
DOI: 10.1128/JVI.68.12.8386-8391.1994
PMCID: PMC237308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7966631-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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