Cooperative effect of the attenuation determinants derived from poliovirus sabin 1 strain is essential for attenuation of enterovirus 71 in the NOD/SCID mouse infection model.

doi:10.1128/JVI.01798-07

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Article

Cooperative effect of the attenuation determinants derived from poliovirus sabin 1 strain is essential for attenuation of enterovirus 71 in the NOD/SCID mouse infection model.

Journal of virology - 1 Feb 2008

Arita Minetaro, Ami Yasushi, Wakita Takaji, Shimizu Hiroyuki

Abstract excerpt

Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and is also associated with serious neurological disorders. An attenuated EV71 strain [EV71(S1-3')] has been established in the cynomolgus monkey infection model; this strain contains the attenuation determinants derived from the type 1 poliovirus vaccine strain, Sabin 1 [PV1(Sabin)], in the 5' nontranslated region (NTR), 3D polymerase,...

Topics

Amino Acid Substitution
Animals
Capsid Proteins
Disease Models, Animal
Enterovirus
Enterovirus Infections
Heart
Mice
Mice, Inbred NOD
Mice, SCID
Muscle, Skeletal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Myocardium

Poliovirus

Poliovirus Vaccine, Oral

Vaccines, Attenuated

Virion

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 18057246
DOI: 10.1128/JVI.01798-07
PMCID: PMC2258712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18057246-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Cooperative effect of the attenuation determinants derived from poliovirus sabin 1 strain is essential for attenuation of enterovirus 71 in the NOD/SCID mouse infection model.PMID 18057246Read ↗

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