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Article

Elongation activity of poliovirus RNA polymerase derived from Sabin type 1 sequence is not temperature sensitive.

The Journal of general virology - 1 Aug 1995

Baker S, Richards O C, Ehrenfeld E

Abstract excerpt

Determinants of attenuation in the Sabin type 1 strain of poliovirus are located in the 5' noncoding region, the capsid coding region and the viral RNA-dependent RNA polymerase (3Dpol) coding region. These mutations also contribute to a temperature sensitive pheno-type of virus replication. We have cloned and expressed the Sabin 1 virus 3Dpol) protein which contains three amino acid differences from the wild-type...

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Source

Identifiers

PMID: 7636491
DOI: 10.1099/0022-1317-76-8-2081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Elongation activity of poliovirus RNA polymerase derived from Sabin type 1 sequence is not temperature sensitive.PMID 7636491Read ↗

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