Elongation activity of poliovirus RNA polymerase derived from Sabin type 1 sequence is not temperature sensitive.

doi:10.1099/0022-1317-76-8-2081

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Article

Elongation activity of poliovirus RNA polymerase derived from Sabin type 1 sequence is not temperature sensitive.

The Journal of general virology - 1 Aug 1995

Baker S, Richards O C, Ehrenfeld E

Abstract excerpt

Determinants of attenuation in the Sabin type 1 strain of poliovirus are located in the 5' noncoding region, the capsid coding region and the viral RNA-dependent RNA polymerase (3Dpol) coding region. These mutations also contribute to a temperature sensitive pheno-type of virus replication. We ha...

Topics

Cloning, Molecular
Genes, Viral
Hot Temperature
Humans
Mutation
Poliovirus
Poliovirus Vaccine, Oral
Poly U
RNA-Dependent RNA Polymerase
Recombinant Proteins
Vaccines, Attenuated
Viral Structural Proteins

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