Article
Identical genetic changes in different histologic components of Wilms' tumors.
Journal of the National Cancer Institute - 6 Aug 1997
Zhuang Z, Merino M J, Vortmeyer A O, Bryant B, Lash A E, Wang C, Deavers M T, Shelton W F, Kapur S, Chandra R S
Abstract excerpt
BACKGROUND: In young children and infants, Wilms' tumor is the most common cancer of the kidney. Wilms' tumor exhibits heterogeneous histopathologic features, consisting of rapidly proliferating blastemal and epithelial cells and a stromal component that has heterologous elements (e.g., cartilage, bone, and striated muscle). It is unclear whether the stromal and heterologous components of sporadic Wilms' tumor...
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