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Article

Allelic loss on chromosome 11p is a less frequent event in bilateral than in unilateral Wilms' tumours.

European journal of cancer (Oxford, England : 1990) - 1 Jan 1992

Little M H, Clarke J, Byrne J, Dunn R, Smith P J

Abstract excerpt

Analyses to detect loss of heterozygosity (LOH) were performed at 11 polymorphic loci on chromosome 11 and, using a polymorphic CA repeat sequence in the WT1 gene, on a series of 39 tumours from 28 unilateral and 10 tumours from 6 bilateral Wilms' tumour (WT) patients. LOH was seen in 13 out of 35 patients including 12 out of 29 unilateral tumours, but only one of 10 bilateral tumours. This suggests that...

Topics

Alleles
Base Sequence
Chromosomes, Human, Pair 11
DNA, Neoplasm
Gene Deletion
Gene Rearrangement
Genes, Wilms Tumor
Humans
Kidney Neoplasms
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms, Multiple Primary

Polymorphism, Restriction Fragment Length

Wilms Tumor

Source

Identifiers

PMID: 1356388
DOI: 10.1016/0959-8049(92)90027-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1356388-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Allelic loss on chromosome 11p is a less frequent event in bilateral than in unilateral Wilms' tumours.PMID 1356388Read ↗

Genetic and epigenetic alterations on the short arm of chromosome 11 are involved in a majority of sporadic Wilms' tumours.Semantic proximity Read ↗

Mutations/deletions of the WT1 gene, loss of heterozygosity on chromosome arms 11p and 11q, chromosome ploidy and histology in Wilms' tumors in Japan.Semantic proximity Read ↗

Genetic mosaicism in normal tissues of Wilms' tumour patients.Semantic proximity Read ↗

Identification of mutations in the WT1 gene in tumours from patients with the WAGR syndrome.Semantic proximity Read ↗

Constitutional and somatic mutations in the WT1 gene in Wilms' tumor patients.Semantic proximity Read ↗

Loss of heterozygosity at 11p13 in Wilms' tumours does not necessarily involve mutations in the WT1 gene.Semantic proximity Read ↗

Correlation of germ-line mutations and two-hit inactivation of the <i>WT1</i> gene with Wilms tumors of stromal–predominant histologySemantic proximity Read ↗

Loss of heterozygosity in bilateral breast cancer.Semantic proximity Read ↗

Identical genetic changes in different histologic components of Wilms' tumors.Semantic proximity Read ↗

WT1 gene analysis in sporadic early-onset and bilateral wilms tumor patients without associated abnormalities.Semantic proximity Read ↗

Bilateral wilms tumor with TP53-related anaplasia.Semantic proximity Read ↗

Bilateral Wilms tumor and early presentation in pediatric patients is associated with the truncation of the Wilms tumor 1 protein.Semantic proximity Read ↗

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