Article
Loss of heterozygosity at 7p in Wilms' tumour development.
British journal of cancer - 1 Jan 2000
Powlesland R M, Charles A K, Malik K T, Reynolds P A, Pires S, Boavida M, Brown K W
Abstract excerpt
Chromosome 7p alterations have been implicated in the development of Wilms' tumour (WT) by previous studies of tumour cytogenetics, and by our analysis of a constitutional translocation (t(1;7)(q42;p15)) in a child with WT and radial aplasia. We therefore used polymorphic microsatellite markers on 7p for a loss of heterozygosity (LOH) study, and found LOH in seven out of 77 informative WTs (9%). The common region...
Topics
- Cell Transformation, Neoplastic
- Child
- Chromosomes, Human, Pair 7
- Disease Progression
- Female
- Germ-Line Mutation
- Humans
- Kidney Neoplasms
- Loss of Heterozygosity
- Male
- Phenotype
- Wilms Tumor