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Article

Loss of heterozygosity at 7p in Wilms' tumour development.

British journal of cancer - 1 Jan 2000

Powlesland R M, Charles A K, Malik K T, Reynolds P A, Pires S, Boavida M, Brown K W

Abstract excerpt

Chromosome 7p alterations have been implicated in the development of Wilms' tumour (WT) by previous studies of tumour cytogenetics, and by our analysis of a constitutional translocation (t(1;7)(q42;p15)) in a child with WT and radial aplasia. We therefore used polymorphic microsatellite markers on 7p for a loss of heterozygosity (LOH) study, and found LOH in seven out of 77 informative WTs (9%). The common region...

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Source

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Identifiers

PMID: 10646884
DOI: 10.1054/bjoc.1999.0922
PMCID: PMC2363297

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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