Article
Genome-wide loss of maternal alleles in a nephrogenic rest and Wilms' tumour from a BWS patient.
Human genetics - 1 Jun 1995
Hoban P R, Heighway J, White G R, Baker B, Gardner J, Birch J M, Morris-Jones P, Kelsey A M
Abstract excerpt
A patient with Beckwith-Wiedemann syndrome (BWS) presented with Wilms' tumour. Examination of the nephrectomy specimen showed, in addition to the tumour, the presence of nephrogenic rests. Nephrogenic rests are thought to be precursor lesions from which a Wilms' tumour may develop. A molecular analysis examining the loss of constitutional heterozygosity (LOCH), initially for chromosome 11, was performed on...
Topics
- Alleles
- Beckwith-Wiedemann Syndrome
- Chromosomes, Human, Pair 11
- Female
- Gene Deletion
- Genome, Human
- Humans
- Infant
- Kidney Neoplasms
- Ploidies
- Polymerase Chain Reaction