Article
Mitogenic effects of pertussis toxin-sensitive G-protein alpha subunits: the mitogenic action of alpha i2 in NIH 3T3 cells is mimicked by alpha i1, but not alpha i3.
Cellular signalling - 1 Mar 1993
Hermouet S, de Mazancourt P, Spiegel A M
Abstract excerpt
In fibroblasts and other cell types, pertussis toxin (PTX) inhibits DNA synthesis in response to serum and certain growth factors. GTPase deficient forms of the PTX-sensitive G-protein alpha i2 subunit have been shown to induce partial transformation in fibroblasts. In order to determine whether...
Topics
- 3T3 Cells
- Adenylate Cyclase Toxin
- Animals
- Cell Division
- Colforsin
- Contact Inhibition
- Cyclic AMP
- GTP-Binding Proteins
- Mice
- Mitogens
- Mutation
- Pertussis Toxin
- Transfection
- Virulence Factors, Bordetella