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Article

Analysis of the fibroblast transformation potential of GTPase-deficient gip2 oncogenes.

Molecular and cellular biology - 1 Jan 1992

Gupta S K, Gallego C, Lowndes J M, Pleiman C M, Sable C, Eisfelder B J, Johnson G L

Abstract excerpt

Expression of GTPase-deficient Gi2 alpha subunit (alpha i2) mutant polypeptides and overexpression of the wild-type alpha i2 polypeptide in Rat 1a, Swiss 3T3, and NIH 3T3 fibroblasts altered normal growth regulation and induced a loss of contact inhibition. In Rat 1a cells (but not in NIH 3T3 or Swiss 3T3 cells), expression of the GTPase-deficient alpha i2 mutant polypeptides allowed colony formation in soft...

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Identifiers

PMID: 1729598
DOI: 10.1128/mcb.12.1.190-197.1992
PMCID: PMC364083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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