Article
Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated.
Circulation research - 1 Nov 1996
Pietruck F, Moritz A, Montemurro M, Sell A, Busch S, Rosskopf D, Virchow S, Esche H, Brockmeyer N, Jakobs K H, Siffert W
Abstract excerpt
Recent studies have shown an enhanced signaling capacity of receptors coupled to pertussis toxin (PTX)-sensitive guanine nucleotide-binding proteins (G proteins) in immortalized B lymphoblasts from patients with essential hypertension. In the present study, we analyzed (1) whether such alterations would also be expressed in nontransformed cells of these individuals and (2) whether other G protein-mediated...
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