Article
Expression of an oncogenic mutant G alpha i2 activates Ras in Rat-1 fibroblast cells.
FEBS letters - 27 Nov 1998
Edamatsu H, Kaziro Y, Itoh H
Abstract excerpt
It has been reported that expression of the active mutant of heterotrimeric GTP-binding protein alpha subunit G alpha i2 transforms Rat-1 cells. However, the G alpha i2-mediated mitogenic signaling pathways remain to be elucidated. Here, we demonstrate that inducible expression of the active mutant of G alpha i2 (G alpha i2(Q205L)) activates Ras and c-Jun N-terminal kinase (JNK) in addition to extracellular...
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