Article
Expression of an oncogenic mutant G alpha i2 activates Ras in Rat-1 fibroblast cells.
FEBS letters - 27 Nov 1998
Edamatsu H, Kaziro Y, Itoh H
Abstract excerpt
It has been reported that expression of the active mutant of heterotrimeric GTP-binding protein alpha subunit G alpha i2 transforms Rat-1 cells. However, the G alpha i2-mediated mitogenic signaling pathways remain to be elucidated. Here, we demonstrate that inducible expression of the active muta...
Topics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Cell Transformation, Neoplastic
- Enzyme Activation
- Epidermal Growth Factor
- Escherichia coli
- Fibroblasts
- Flavonoids
- GTP-Binding Protein alpha Subunit, Gi2
- GTP-Binding Protein alpha Subunits, Gi-Go