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Article

Expression, activity and cytotoxicity of pertussis toxin S1 subunit in transfected mammalian cells.

Cellular microbiology - 1 Jan 2001

Castro M G, McNamara U, Carbonetti N H

Abstract excerpt

Pertussis toxin (PT) comprises an active subunit (S1), which ADP-ribosylates the alpha subunit of several mammalian G proteins, and the B oligomer (S2-S5), which binds glycoconjugate receptors on cells. In a previous report, expression of S1 in Cos cells resulted in no observable cytotoxicity, and it was hypothesized that either S1 failed to locate its target proteins or the B oligomer was also necessary for...

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Identifiers

PMID: 11207619
DOI: 10.1046/j.1462-5822.2001.00092.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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