Article
GTPase-deficient G alpha i2 oncogene gip2 inhibits adenylylcyclase and attenuates receptor-stimulated phospholipase A2 activity.
The Journal of biological chemistry - 5 Aug 1991
Lowndes J M, Gupta S K, Osawa S, Johnson G L
Abstract excerpt
The GTPase activity of a G protein alpha subunit functions as a timer to control the lifetime of the activated conformation of the protein. Expression of the GTPase-deficient Gi2 alpha subunit oncogene, gip2 (alpha i2Q205L), in Chinese hamster ovary cells inhibited the stimulation of adenylylcycl...
Topics
- Adenosine Triphosphate
- Adenylyl Cyclase Inhibitors
- Animals
- Arachidonic Acid
- Arachidonic Acids
- Base Sequence
- Calcium
- Cricetinae
- Cricetulus
- GTP Phosphohydrolases
- GTP-Binding Proteins
- Ionomycin
- Molecular Sequence Data
- Mutation
- Oncogenes
- Phenotype
- Phospholipases A
- Phospholipases A2