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Article

Single amino acid codon changes detected in louping ill virus antibody-resistant mutants with reduced neurovirulence.

The Journal of general virology - 1 May 1993

Jiang W R, Lowe A, Higgs S, Reid H, Gould E A

Abstract excerpt

Seven mutant viruses were derived from a Scottish strain of louping ill virus using a virus envelope-specific neutralizing monoclonal antibody. None of the mutants was neutralized and immunofluorescence microscopy confirmed that they did not bind to this antibody. Four mutants showed reduced mouse neurovirulence compared with parent virus and two mutants failed to induce protective immune responses in mice...

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PMID: 8388021
DOI: 10.1099/0022-1317-74-5-931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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