Article
Single amino acid codon changes detected in louping ill virus antibody-resistant mutants with reduced neurovirulence.
The Journal of general virology - 1 May 1993
Jiang W R, Lowe A, Higgs S, Reid H, Gould E A
Abstract excerpt
Seven mutant viruses were derived from a Scottish strain of louping ill virus using a virus envelope-specific neutralizing monoclonal antibody. None of the mutants was neutralized and immunofluorescence microscopy confirmed that they did not bind to this antibody. Four mutants showed reduced mous...
Topics
- Animals
- Antibodies, Viral
- Base Sequence
- Cell Line
- Codon
- DNA, Viral
- Encephalitis Viruses, Tick-Borne
- Mice
- Molecular Sequence Data
- Mutation
- Neutralization Tests
- Polymerase Chain Reaction
- Swine
- Viral Envelope Proteins
- Virulence