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Article

Characterization of temperature-sensitive Akabane virus mutants and their roles in attenuation.

Archives of virology - 1 Jan 2007

Ogawa Y, Kato K, Tohya Y, Akashi H

Abstract excerpt

Akabane virus (AKAV) of the genus Orthobunyavirus in the family Bunyaviridae is an important animal pathogen; however, studies on AKAV biology are scarce. Therefore, we generated temperature-sensitive (ts) mutants of AKAV in order to study its pathogenesis. The ts AKAV mutants were generated by incubating the virulent OBE-1 strain with the chemical mutagen 5-fluorouracil. Each ts mutant was inoculated...

Topics

Animals
Animals, Suckling
Bunyaviridae
Cell Line
Cricetinae
Mice
Mice, Inbred BALB C
Mutation
Phenotype
RNA, Viral
Temperature
Vaccines, Attenuated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Proteins

Virus Inactivation

Source

Identifiers

PMID: 17533552
DOI: 10.1007/s00705-007-0991-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17533552-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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