Article
Recently Identified Mutations in the Ebola Virus-Makona Genome Do Not Alter Pathogenicity in Animal Models.
Cell reports - 8 May 2018
Marzi Andrea, Chadinah Spencer, Haddock Elaine, Feldmann Friederike, Arndt Nicolette, Martellaro Cynthia, Scott Dana P, Hanley Patrick W, Nyenswah Tolbert G, Sow Samba, Massaquoi Moses, Feldmann Heinz
Abstract excerpt
Ebola virus (EBOV), isolate Makona, the causative agent of the West African EBOV epidemic, has been the subject of numerous investigations to determine the genetic diversity and its potential implication for virus biology, pathogenicity, and transmissibility. Despite various mutations that have emerged over time through multiple human-to-human transmission chains, their biological relevance remains questionable....
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