Article
A mutation in the envelope protein fusion loop attenuates mouse neuroinvasiveness of the NY99 strain of West Nile virus.
Virology - 15 Sept 2006
Zhang Shuliu, Li Li, Woodson Sara E, Huang Claire Y-H, Kinney Richard M, Barrett Alan D T, Beasley David W C
Abstract excerpt
Substitutions were engineered individually and in combinations at the fusion loop, receptor-binding domain and a stem-helix structure of the envelope protein of a West Nile virus strain, NY99, and their effects on mouse virulence and presentation of epitopes recognized by monoclonal antibodies (MAbs) were assessed. A single substitution within the fusion loop (L107F) attenuated mouse neuroinvasiveness of NY99. No...
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