Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuroinvasiveness of the MR766 strain of Zika virus in IFNAR-/- mice maps to prM residues conserved amongst African genotype viruses.

PLoS pathogens - 1 Jul 2021

Nakayama Eri, Kato Fumihiro, Tajima Shigeru, Ogawa Shinya, Yan Kexin, Takahashi Kenta, Sato Yuko, Suzuki Tadaki, Kawai Yasuhiro, Inagaki Takuya, Taniguchi Satoshi, Le Thuy T, Tang Bing, Prow Natalie A, Uda Akihiko, Maeki Takahiro, Lim Chang-Kweng, Khromykh Alexander A, Suhrbier Andreas, Saijo Masayuki

Abstract excerpt

Zika virus (ZIKV) strains are classified into the African and Asian genotypes. The higher virulence of the African MR766 strain, which has been used extensively in ZIKV research, in adult IFNα/β receptor knockout (IFNAR-/-) mice is widely viewed as an artifact associated with mouse adaptation due to at least 146 passages in wild-type suckling mouse brains. To gain insights into the molecular determinants of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood-Brain Barrier
Share to Capillary Permeability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Viral Envelope Proteins

Share to Virulence

Share to Zika Virus

Share to Zika Virus Infection

Source

Open in PubMed Open full text

Identifiers

PMID: 34310650
DOI: 10.1371/journal.ppat.1009788
PMCID: PMC8341709

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuroinvasiveness of the MR766 strain of Zika virus in IFNAR-/- mice maps to prM residues conserved amongst African genotype viruses.PMID 34310650Read ↗

Two Genetic Differences between Closely Related Zika Virus Strains Determine Pathogenic Outcome in Mice.Semantic proximity Read ↗

A single amino acid substitution in the capsid protein of Zika virus contributes to a neurovirulent phenotypeSemantic proximity Read ↗

Influence of Zika virus 3′-end sequence and nonstructural protein evolution on the viral replication competence and virulenceSemantic proximity Read ↗

Differential Neurovirulence of African and Asian Genotype Zika Virus Isolates in Outbred Immunocompetent Mice.Semantic proximity Read ↗

Zika structural genes determine the virulence of African and Asian lineages.Semantic proximity Read ↗

Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) miceSemantic proximity Read ↗

Leu-to-Phe substitution at prM146 decreases the growth ability of Zika virus and partially reduces its pathogenicity in mice.Semantic proximity Read ↗

The distinguishing NS5-M114V mutation in American Zika virus isolates has negligible impacts on virus replication and transmission potential.Semantic proximity Read ↗

A natural polymorphism in Zika virus NS2A protein responsible of virulence in miceSemantic proximity Read ↗

The African strain of Zika virus causes more severe in utero infection than Asian strain in a porcine fetal transmission modelSemantic proximity Read ↗

The NS1 protein of contemporary West African Zika virus is efficient to increase cellular permissiveness to virus replicationSemantic proximity Read ↗

An Attenuated Zika Virus Encoding Non-Glycosylated Envelope (E) and Non-Structural Protein 1 (NS1) Confers Complete Protection against Lethal Challenge in a Mouse ModelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.