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Article

West Nile virus envelope proteins: nucleotide sequence analysis of strains differing in mouse neuroinvasiveness.

1 Oct 1998

Abstract excerpt

Several neuroinvasive and non-neuroinvasive West Nile (WN) viruses were characterized by nucleotide sequencing of their envelope (E) protein regions. Prolonged passage in mosquito cells caused loss of neuroinvasiveness and acquisition of an N-linked glycosylation site, which is utilized. Limited passage in cell culture also caused glycosylation but not attenuation, suggesting that glycosylation may not be...

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PMID: 9780042
DOI: 10.1099/0022-1317-79-10-2375

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