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In Vitro and in Vivo Evaluation of Mutations in the NS Region of Lineage 2 West Nile Virus Associated with Neuroinvasiveness in a Mammalian Model.

Viruses - 19 Feb 2016

Szentpáli-Gavallér Katalin, Lim Stephanie M, Dencső László, Bányai Krisztián, Koraka Penelope, Osterhaus Albert D M E, Martina Byron E E, Bakonyi Tamás, Bálint Ádám

Abstract excerpt

West Nile virus (WNV) strains may differ significantly in neuroinvasiveness in vertebrate hosts. In contrast to genetic lineage 1 WNVs, molecular determinants of pathogenic lineage 2 strains have not been experimentally confirmed so far. A full-length infectious clone of a neurovirulent WNV lineage 2 strain (578/10; Central Europe) was generated and amino acid substitutions that have been shown to attenuate...

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Identifiers

PMID: 26907325
DOI: 10.3390/v8020049
PMCID: PMC4776204

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Source receipt: pubmed, retrieved 7 Sept 2026.

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