Article
RXR-dependent and RXR-independent transactivation by retinoic acid receptors.
Nucleic acids research - 11 Mar 1993
Schräder M, Wyss A, Sturzenbecker L J, Grippo J F, LeMotte P, Carlberg C
Abstract excerpt
The binding affinity of retinoic acid receptors (RARs) to their response elements is strongly enhanced in vitro by the formation of heterodimers with retinoid X receptors (RXRs) suggesting that heterodimerization with RXR may be a prerequisite for a RAR-mediated transcriptional response. We found...
Topics
- Animals
- Base Sequence
- Carrier Proteins
- Cell Line
- DNA
- Drosophila
- Humans
- Molecular Sequence Data
- Mutation
- Receptors, Cell Surface
- Receptors, Retinoic Acid
- Retinoid X Receptors
- Transcription Factors
- Transcriptional Activation
- Tretinoin
- Tumor Cells, Cultured