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Article

RXR-dependent and RXR-independent transactivation by retinoic acid receptors.

Nucleic acids research - 11 Mar 1993

Schräder M, Wyss A, Sturzenbecker L J, Grippo J F, LeMotte P, Carlberg C

Abstract excerpt

The binding affinity of retinoic acid receptors (RARs) to their response elements is strongly enhanced in vitro by the formation of heterodimers with retinoid X receptors (RXRs) suggesting that heterodimerization with RXR may be a prerequisite for a RAR-mediated transcriptional response. We found that in Drosophila SL-3 cells that are devoid of endogenous RARs and RXRs the presence of RAR is sufficient to confer...

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Identifiers

PMID: 8385314
DOI: 10.1093/nar/21.5.1231
PMCID: PMC309287

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