Article
Thyroid hormone receptor-alpha inhibits retinoic acid-responsive gene expression and modulates retinoic acid-stimulated neural differentiation in mouse embryonic stem cells.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 1994
Lee L R, Mortensen R M, Larson C A, Brent G A
Abstract excerpt
Thyroid hormone (T3) and retinoic acid (RA) are essential for normal vertebrate development and are known to coregulate several genes. Early development is predominantly retinoic acid sensitive, yet thyroid hormone receptor-alpha (T3R alpha) is expressed along with retinoic acid receptors (RAR)-a...
Topics
- Alkaline Phosphatase
- Alleles
- Animals
- Blotting, Western
- Cell Differentiation
- Cell Line
- DNA
- Gene Expression Regulation
- Gene Expression Regulation, Enzymologic
- Mice
- Neurons
- RNA, Messenger
- Receptors, Retinoic Acid
- Receptors, Thyroid Hormone
- Sequence Homology, Nucleic Acid
- Stem Cells
- Transfection
- Tretinoin