Article
Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells.
Molecular and cellular biology - 1 Jan 1994
Minucci S, Zand D J, Dey A, Marks M S, Nagata T, Grippo J F, Ozato K
Abstract excerpt
Retinoid X receptors (RXRs) heterodimerize with multiple nuclear hormone receptors and are thought to exert pleiotropic functions. To address the role of RXRs in retinoic acid- (RA) mediated gene regulation, we designed a dominant negative RXR beta. This mutated receptor, termed DBD-, lacked the...
Topics
- Animals
- Base Sequence
- Carcinoma, Embryonal
- Cell Differentiation
- Cell Division
- DNA Primers
- DNA, Neoplasm
- Gene Expression Regulation, Neoplastic
- Genes, Reporter
- Mice
- Molecular Sequence Data
- Mutation
- Receptors, Cytoplasmic and Nuclear
- Receptors, Retinoic Acid
- Retinoid X Receptors