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Article

Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells.

Molecular and cellular biology - 1 Jan 1994

Minucci S, Zand D J, Dey A, Marks M S, Nagata T, Grippo J F, Ozato K

Abstract excerpt

Retinoid X receptors (RXRs) heterodimerize with multiple nuclear hormone receptors and are thought to exert pleiotropic functions. To address the role of RXRs in retinoic acid- (RA) mediated gene regulation, we designed a dominant negative RXR beta. This mutated receptor, termed DBD-, lacked the DNA binding domain but retained the ability to dimerize with partner receptors, resulting in formation of nonfunctional...

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Identifiers

PMID: 8264603
DOI: 10.1128/mcb.14.1.360-372.1994
PMCID: PMC358385

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